Anne E Lykkesfeldt Selected Research

Estrogen Receptor Modulators (Antiestrogen)

8/2018	A suppressive role of guanine nucleotide-binding protein subunit beta-4 inhibited by DNA methylation in the growth of anti-estrogen resistant breast cancer cells.
3/2016	HIF2α contributes to antiestrogen resistance via positive bilateral crosstalk with EGFR in breast cancer cells.
4/2015	Aurora kinase B is important for antiestrogen resistant cell growth and a potential biomarker for tamoxifen resistant breast cancer.
1/2015	Altered radiation responses of breast cancer cells resistant to hormonal therapy.
1/2015	SRC drives growth of antiestrogen resistant breast cancer cell lines and is a marker for reduced benefit of tamoxifen treatment.
7/2014	1α,25-dihydroxyvitamin D3 inhibits cell growth and NFκB signaling in tamoxifen-resistant breast cancer cells.
7/2014	The broad-spectrum metalloproteinase inhibitor BB-94 inhibits growth, HER3 and Erk activation in fulvestrant-resistant breast cancer cell lines.
3/2014	T47D breast cancer cells switch from ER/HER to HER/c-Src signaling upon acquiring resistance to the antiestrogen fulvestrant.
11/2012	Carboplatin treatment of antiestrogen-resistant breast cancer cells.
8/2012	NFκB signaling is important for growth of antiestrogen resistant breast cancer cells.

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Anne E Lykkesfeldt Research Topics

Disease

52	Breast Neoplasms (Breast Cancer) 01/2021 - 03/2003
32	Neoplasms (Cancer) 01/2021 - 03/2003
2	Williams Syndrome (Williams-Beuren Syndrome) 01/2018 - 01/2013
2	Neoplasm Metastasis (Metastasis) 12/2015 - 01/2009
2	Adenocarcinoma 01/2015 - 01/2010
2	Carcinoma (Carcinomatosis) 01/2014 - 06/2009
1	Pathologic Processes 08/2018
1	Hypoxia (Hypoxemia) 03/2016
1	Choriocarcinoma 01/2010
1	Schizophrenia (Dementia Praecox) 09/2009
1	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 05/2003

Drug/Important Bio-Agent (IBA)

31	Tamoxifen FDA LinkGeneric 01/2021 - 04/2003
29	Estrogen ReceptorsIBA 01/2021 - 03/2003
18	Estrogen Receptor Modulators (Antiestrogen)IBA 08/2018 - 03/2003
14	Estrogens (Estrogen)FDA Link 08/2018 - 03/2003
12	Fulvestrant (Faslodex)FDA Link 08/2018 - 03/2009
10	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2004
10	Letrozole (Femara)FDA LinkGeneric 01/2021 - 01/2008
7	Biomarkers (Surrogate Marker)IBA 01/2021 - 06/2009
7	Estrogen Receptor alphaIBA 06/2010 - 01/2004
6	Progesterone Receptors (Progesterone Receptor)IBA 01/2018 - 04/2007
6	Aromatase InhibitorsIBA 12/2015 - 03/2003
6	Hormones (Hormone)IBA 01/2015 - 10/2003
6	ErbB Receptors (EGF Receptor)IBA 07/2014 - 03/2009
4	Phosphotransferases (Kinase)IBA 04/2015 - 11/2014
4	Aromatase (CYP19)IBA 04/2015 - 06/2009
3	Transcription Factors (Transcription Factor)IBA 01/2018 - 01/2013
3	Pharmaceutical PreparationsIBA 06/2016 - 10/2003
3	exemestane (Aromasin)FDA Link 04/2015 - 01/2013
3	EnzymesIBA 01/2014 - 12/2007
3	Selective Estrogen Receptor Modulators (SERM)IBA 12/2007 - 04/2004
2	Aurora Kinase AIBA 01/2018 - 02/2015
2	Anastrozole (Arimidex)FDA LinkGeneric 04/2015 - 01/2013
2	Vitamin D FDA LinkGeneric 07/2014 - 01/2013
2	Messenger RNA (mRNA)IBA 12/2013 - 12/2007
2	Cisplatin (Platino)FDA LinkGeneric 11/2012 - 06/2007
2	LY 353381 (LY353381)IBA 05/2004 - 04/2004
1	Minichromosome Maintenance ProteinsIBA 01/2021
1	Carrier Proteins (Binding Protein)IBA 08/2018
1	Biological ProductsIBA 08/2018
1	Guanine NucleotidesIBA 08/2018
1	palbociclibIBA 11/2016
1	MicroRNAs (MicroRNA)IBA 08/2016
1	IntegrinsIBA 06/2016
1	Protein Isoforms (Isoforms)IBA 06/2016
1	Trefoil Factor-3IBA 12/2015
1	2- ((3- ((4- ((5- (2- ((3- fluorophenyl)amino)- 2- oxoethyl)- 1H- pyrazol- 3- yl)amino)quinazolin- 7- yl)oxy)propyl)(ethyl)amino)ethyl dihydrogen phosphateIBA 04/2015
1	Aurora Kinase BIBA 04/2015
1	AndrogensIBA 04/2015
1	Aurora KinasesIBA 02/2015
1	nilotinib FDA Link 11/2014
1	Sorafenib (BAY 43-9006)FDA Link 11/2014
1	batimastat (BB 94)IBA 07/2014
1	Metalloproteases (Metalloproteinases)IBA 07/2014
1	LigandsIBA 07/2014
1	Advanced Glycation End ProductsIBA 01/2014
1	AldehydesIBA 01/2014
1	Phenobarbital (Luminal)FDA Link 01/2013
1	Calcitriol Receptors (Calcitriol Receptor)IBA 01/2013
1	seocalcitolIBA 01/2013
1	RNA (Ribonucleic Acid)IBA 01/2013
1	Carboplatin (JM8)FDA LinkGeneric 11/2012
1	Gefitinib (Iressa)FDA Link 07/2011
1	Lapatinib (GW572016)FDA Link 03/2010
1	Testosterone (Sustanon)FDA Link 01/2010
1	Chlorpromazine (Thorazine)FDA Link 09/2009
1	Member 1 Subfamily B ATP Binding Cassette TransporterIBA 09/2009
1	Antipsychotic Agents (Antipsychotics)IBA 09/2009
1	thiamine triphosphorate (TTP)IBA 01/2009
1	Formaldehyde (Formol)FDA Link 01/2009
1	ParaffinIBA 01/2009
1	Tyrosine (L-Tyrosine)FDA Link 01/2009
1	Steryl-Sulfatase (Steroid Sulfatase)IBA 12/2007
1	21- (2- N,N- diethylaminoethyl)oxy- 7- methyl- 19- norpregna- 1,3,5(10)- triene- 3- O- sulfamateIBA 12/2007
1	SteroidsIBA 12/2007
1	CaspasesIBA 10/2007
1	Casein Kinase II (Casein Kinase 2)IBA 10/2007
1	Protein Kinase C-alphaIBA 08/2007
1	desmethylarzoxifeneIBA 05/2004
1	Growth InhibitorsIBA 04/2004
1	OligonucleotidesIBA 01/2004
1	Cyclin-Dependent Kinase Inhibitor p21IBA 01/2004
1	Heat-Shock Proteins (Heat-Shock Protein)IBA 10/2003
1	geldanamycinIBA 10/2003
1	tanespimycin (17AAG)IBA 10/2003
1	Interleukin-6 (Interleukin 6)IBA 05/2003
1	Estradiol (Delestrogen)FDA LinkGeneric 03/2003

Therapy/Procedure

22	Therapeutics 01/2021 - 03/2003
3	Drug Therapy (Chemotherapy) 12/2015 - 07/2012
1	Adjuvant Chemotherapy 09/2017
1	Radiotherapy 01/2015
1	Neoadjuvant Therapy 07/2011
1	Lasers (Laser) 10/2003